Showing posts with label public science. Show all posts
Showing posts with label public science. Show all posts

Tuesday, August 5, 2014

Summer Assignment 8.4

  • Ebola virus has been in the news quite a bit lately, and being the virus fan that I am, I can't let the opportunity pass. But instead of the usual stuff here are some good reasons not to worry too much about it.
  •  I wouldn't normally link to a Cosmo post, but since this one has a picture of flesh-eating beetles, I can't resist. Oh, and it is also the great story of an artist turned scientist/science educator.

Wednesday, July 18, 2012

Summer Assignment 7.20

Thanks for all the great comments last week. Remember, if you are going on vacation and don't think you will be able to access the site to comment, please drop me an email with the dates.

  • With the Olympics around the corner, this article looks at the bio-mechanics of sprinting, and if the 9-second mark will ever be broken in the 100 m sprint. Interesting that swing time (the time between steps) is equivalent for all runners at top speed. The men's 100m final is August 5th; the women's is the day before.
  • What are the most important science questions the presidential should answer? Here is a list of 14 good ones. Four years ago, the McCain and Obama campaigns posted responses to science questions. I wouldn't hold my breath for a science-themed debate, but if you go here you can vote for your choice for moderator. This guy is winning, and would be awesome.

Friday, July 13, 2012

Summer Assignment 7.13

Welcome to the first official post of the 2012 AP Biology Summer Blog. The rules are simple:

1. Check out the links I include in the post.
2. Make an intelligent comment on them.
3. Or respond in an intelligent way to someone else's comment.
4. Earn points!

Just a note, you don't need to read all of the links I post when there are multiple stories linked. You can always pick the ones that seem most interesting to you.

On to the links:

Tuesday, July 26, 2011

Summer Assignment: 7.26

Before the links, just a quick reminder about comments. I have been getting many emails wondering why comments are not showing up. Some of these have been actual issues, but most of them are just due to the moderation process. Before the comments show up on the post, I read them over and enter them into my gradebook. I try to do this twice a day (early morning and late night), but sometimes I am not able to get on right away. So if your comment does not show up right away, give it 24 hours before sending me an email. If i am going to be away for a few days, I will try let you guys know first. Thanks. Onto the posts:

Parasitic Wasp Employs Zombie Ladybug to Guard Cocoon

Parasites are so cool. Two weeks ago, there was a link to a story about how they are believed to be one of the driving forces behind the evolution of sexual reproduction. This week, zombies. Lots of good stuff mentioned in this post: evolution of bees, co-evolution, evolution of the stinger. I may try to mention parasites everyday this year in class.

How Advertising Manipulates Your Choices and Spending Habits (And What to do About it)

Not a biology-related post, but I still thought this was interesting, and also somewhat important. The author sort of lost me with the last two paragraphs, about how a world without ads would be the end of Western Civilization as We Know It. But i will say that I have gotten so used to Ad Block Plus on my browser, that when I am forced to use a computer without it, it is jarring to see all the ads. So if you don't have ABP installed, get it today (www.adblockplus.org).

Anyway, back to the post. Lots of great points here, and I love the "reference lifestyles" concept. And though I never watched Friends, I seem to recall they explained that huge apartment by saying it was rent-controlled from someone's grandmother or something. Any Friends fans out there back me up on this?

I feel that the most important message from this is to simply THINK. All. The. Time. Whether the purchase is a $35,000 car, or a $1.99 smartphone app (I hate Angry Birds for stealing my life), you should always ask yourself about why you are spending money on that particular item. As the author states in the post: intrinsic v. extrinsic motivation.

The ability to critically think and use your brain will be another running theme throughout class next year.

Monday, August 16, 2010

Summer Assignment: 8.17.10

Bacteria Can Have a "Sense of Smell"

Not really all that surprising that bacteria can "smell," or simply detect airborne chemicals. Smell is directly related to taste, as anyone who has tried to eat their favorite meal with a cold can attest to. The only difference in smell and taste is how the chemicals are delivered to the receptors: direct contact for taste and airborne for smell.

The interesting part of the research, to me at least, was the fact that the bacteria respond to different "smells." Ammonia, for example, triggers the formation of a biofilm.

Biofilm is a major cause of infection on medical implants such as heart valves, artificial hips and even breast implants. Also known as 'biofouling' it costs the marine industry millions every year, slowing ships down and wasting precious fuel. But it also has its advantages. Certain biofilms thrive on petroleum oil and can be used to clean up an oil spill.

Algebra and Circuit Breakers
Lots of great points in this post about the current state of math and science education/knowledge. There is a general lack of understanding about math and science in the general public, and I do not just mean that people don't know what DNA stands for, of how to factor a polynomial. It is more important to understand math and science as processes, ways of thinking about and solving a problem, rather than a set of facts to be memorized. I think that this is very nicely illustrated in the linked post by the story of the circuit breakers.

How often do we hear people say "Oh, I'm not a math person, you figure out what the tip should be for lunch"...what if someone said "Oh, I'm not much of a reading person, you tell me what the menu says." Those two statements are really not that different, yet one is OK, and the other signifies a breakdown in the educational system. Why is that? Why is it socially acceptable (and in some cases preferable) to be "not a math/science person" while not being a language person is unheard of. Not knowing how to critically think, weigh evidence and draw a logical, evidence-based conclusion is as integral to math and science education as knowing the difference between verbs and nouns are to language education.

And don't tell me that basic reading is a fundamental life skill while finding percentages is not. The current economic situation has been partly blamed on people's misunderstanding of basic math. And anyway, my point is not about math and science factual knowledge, but using the skills gained in studying them to navigate life.

[The] skills you learn in math go well beyond learning to plug numbers into the quadratic formula. Math is about systematic thinking, and systematic thinking is what built human civilization. Without the ability to think systematically, we'd all be stuck huddling in caves, hoping the lions didn't eat too many of us tonight.

And yes, I am treating math and science as one here, as the author of the post does. One of the other major problems with education is the compartmentalization of learning. This isn't math class, why are we talking about numbers? This is [class x] not [class y], why are we talking about [topic from class x]??? Because everything is connected, and seeing those connections is the hallmark of an educated mind.

Hopefully, if I have done my job as an educator, after taking AP Biology, you will begin to see and appreciate those connections.

Tuesday, August 10, 2010

Summer Assignment: 8.10.10

Pees and Carrots

Sustainable fertilizer may be easier than we think. This is actually a much bigger issue than it seems, since the current practice of using fossil fuels to create fertilizers for industrial farming means that we use 10 Calories of energy for every 1 Calorie of food produced. This is obviously not a sustainable practice for very long. The question is though, will people be willing to pee on their salads before eating them?

Using Blue Whales' Perfect Pitch to Drive People Insane

FINALLY!! Biology has a mad scientist. Too long only chemists and physicists were allowed to hatch mad schemes to take over the world.

I have only to gather a pod of blue whales in the harbor of some Pacific coastal town and make them direct their song landward. The synchronized infrasonic hum, deafening yet inaudible, has the potential to cause anything from high blood pressure to incipient madness in the townspeople. At the very least, it'll produce a hum that some people can hear and others can't, which would be unbearably annoying.

Wednesday, August 26, 2009

Summer Assignment: 8.26

Tools Let Public Contribute to Massive Interactive Online Biodiversity Encyclopedia

Short update on the progress on the Encyclopedia of Life, an effort to catalog all of Earth's species. A very ambitious and worthwhile project. Another similar project is the Tree of Life, which focuses more on the phylogenetic (evolutionary) relationships between species.

Chris Jordan Photographic Arts

A blogger at Ready Made Magazine is trying to survive for a week without plastic. Very interesting concept, I have seen this done a few times before with other materials. But it reminded me of the artwork of Chris Jordan, who creates mosaics using certain numbers of items.



The example above is made of 10000 dog and cat collars, which represents the average number of unwanted dogs and cats euthanized in the US every day. The gallery at his website features close-up views of the work, and most of his others, so that the individual pieces can be seen.

Very powerful work, I highly recommend visiting the site and checking out the two Running the Numbers galleries. A great visual statement on our disposable culture in America.

Wednesday, August 12, 2009

Summer Assignment: 8.12

Babies' Brains Churning With Activity

The idea of "mirror neurons" is very interesting...as you watch someone doing an action, your brain works as if you are doing the action yourself. Could be a very important part of learning motor control.

Tumor Suppressor Pulls Double Shift as Reprogramming Watchdog

Induced pluripotent stem cells (iPSC) could potentially be the key to the future of stem cell based therapies and research. They can provide patients with a population of stem cells that are an exact genetic match, without the moral/ethical issues surrounding other methods of obtaining stem cells.

Vertical Farms

I thought that this was an interesting method to address the food problem in the world. Not sure if they took into account the price of real estate in NYC....

Wednesday, August 5, 2009

Summer Assignment: 8.5

Microbes 'R' Us

Interesting ideas about the role of intestinal flora in human evolution. Why do specific groups have specific bacterial signatures? Do the diets fit the bacteria, or vice versa? Could this play a role in one of the posts from a few weeks ago about humans eventually evolving to be able to handle high-fat diets and not become obese: Since bacteria can evolve so much faster than humans, it is probably much more likely for a fat-metabolizing bacteria to arise than the human genome changing.

How Happy is the Internet?

Very interesting use of the internet in social research; the results from Twitter should be even more enlightening. Some interesting questions raised about popular music too: Is there a relationship between happy lyrics and popularity? As someone who listens to both "sad" (Radiohead, Elbow) and "happy" (Jack Johnson....umm, that's the only happy artist I can think of right now. Maybe I only like sad music...) artists, I think maybe the popularity of the artists may be a reflection of the overall mood of time. Happy mood = happy popular music.

But anyway, how can the internet not be happy when there is stuff like this on there. And this.

Tuesday, July 28, 2009

Summer Assignment: 7.29

Respect For the Fungus Overlords

Only one link today, it is a longer article and I am going out of town (again) tomorrow, and still need to pack...

Carl Zimmer is one of my favorite science authors/bloggers, there is a link to his blog The Loom on the left side of this blog. I recently read his book Parasite Rex, which was about how parasites are integral parts of ecosystems, and in many ways have directed the evolution of their hosts. One idea is that parasites are responsible for the evolution of sexual reproduction, which is actually quite costly and the reasons for it first appearing are unknown.

One thing that is made very clear throughout the book is that a parasitic life style may actually be the "norm" on Earth, rather than something odd or strange. Parasitic life forms may very well be found to outnumber "free-living" organisms.

This particular article highlights some current research on a fungal parasite (Ophiocordyceps unilaterius)of a specific species of ant (Camponotus leonardi). This parasite takes over the body of the ant and causes it to seek a high leaf. From there, the fungus grows out of the ant body and releases spores the forest floor below, which are then able to infect more ants.



The researchers wanted to know if the parasite was actually controlling the ants, or if the ants just got lost along the way, since ants normally do not occupy the specific leaf height where infected ants go to die and release the fungal spores.

And for those of you who may think this research qualifies as frivolous or wasteful,
Like their hosts, parasites face many threats to their survival these days. Just as overfishing may wipe out my dear namesake tapeworm, I worry about the rampant deforestation of tropical forests, which may wipe out not just trees, but the insects that depend on them, and the fungi that depend on them in turn. We should not wish extinction on Ophiocordyceps, as gruesome as it may be. It has much to teach us. We might even borrow some of its tricks–Ophiocordyceps antibiotics show promising signs of fighting against malaria and cancer. And it would be a true shame for this particular bit of science fiction to disappear from the world of science fact.

Also, parasites are just way creepy-cool. If you don't take my word for it, check out the book.

Tuesday, July 21, 2009

Summer Assignment Post for 7.22

Lots of great comments last week...seems like everyone likes to curse when they hurt themselves, and are somewhat skeptical of using rapamycin to increase life span.

Remember to vote in the polls if you have not, and to check back for other student comments all week; the comment section can be a great place for discussion/arguments.

Seemingly "Duh!" Scientific Studies Often Hold Value

I actually looked up one of the studies mentioned in this article: the one about the evolution of tickle-induced laughing. Granted, that may have been just because I had an image in my mind of a bunch of grad students in a lab tickling baby chimps and gorillas, and that made me happy.

And I also found their model of the evolution of this laughter to be interesting...



If you haven't heard this before, you definitely will this year in AP: Everything in Biology can be explained through evolution.

In regards to the original article, do you think there are "frivolous" scientific studies? Or is any and all knowledge worthwhile, simply for the sake of knowledge?


Coping With Excess

I thought this was an interesting idea...will humans eventually evolve to be able to handle Big Macs and not get obese? Not sure... the columnist makes a lot of good points, but I think the most important one may be one of the last ones:
Many factors — what you eat today, what you ate as a baby, levels of exercise, your gut microbes and so on — contribute to obesity.

Something very important to remember, all traits, especially human traits, are very complex and hard to ascribe a cause to.

And the pentailed tree shrew looks like a pretty cool guy...even if there is only the one picture of him.

Tuesday, July 14, 2009

Summer Assignment Post for 7.15

This is the first "official" post for the summer assignment. Take a few minutes to read the linked articles below and make a comment or two on them. You don't need to read all three or comment on all three to get credit...just read whichever ones interest you. Be sure to check back often during the week after you have posted your comment, as you may want to respond to other student's comments, or they may specifically address your comments.

Also, if you have not voted in the two polls on the left side, please do so. The polls are anonymous, so you will not be singled out for your responses.

Darwin's Mystery of Appearance of Flowering Plants Explained

Two ecologists present a possible explanation for the rapid (in evolutionary terms) expansion of angiosperms in the Cretaceous period (100 - 65 million years ago). This problem upset Charles Darwin greatly, and he had no explanation for it when he proposed his framework for evolution by natural selection. I have an essay around here somewhere that goes into more detail about angiosperm evolution, but I am not sure where it is right now....

Anyone have any comments/thought about the mechanism proposed in this article?


A Pill for Longer Life?

Rapamycin, a drug commonly used in humans to prevent transplanted organs from being rejected, has been found to extend the lives of mice by up to 14% — even when given to the mice late in life. [...]until now, the only robust way to extend life in mammals has been to heavily restrict diet.


In terms of the average US life span of 78 years, this would add about 10 years. Would you take a drug that may increase your life span if it meant that you may be more susceptible to infections?


Holy $@%#! Swearing Eases the Pain

I thought this was kind of interesting...but I don't need you to make a list like the researchers had their subjects do.

Friday, February 27, 2009

Links for 2.27.09

Transpiration Lab

Drink Up, Energy Hogs


Are people still drinking that much bottled water? Really??

Deconstructing the Ribosome


Interesting article on the evolution of a highly complex structure - the ribosome.

Tuesday, February 10, 2009

Links: 2.10.09

Projected records: Baseball 2009

Wonder how it would feel in Tampa if the Rays have the second highest win total in franchise history, and yet miss the playoffs. Ouch. As far as the Orioles winning 76 games, which would be an 8 game improvement over last year, I think that sounds about right.

Flu: It's the humidity. Absolutely


Winter is flu season in the world's temperate regions, but scientists still aren't sure why. Now, it turns out that the answer may have been staring them in the face all along. A reanalysis of data from past studies suggests that low absolute humidity--not low relative humidity, the factor many scientists have studied--helps the virus survive and the flu spread.

"Immortal" Jellyfish Swarm World's Oceans

A potentially "immortal" jellyfish species that can age backward—the Benjamin Button of the deep—is silently invading the world's oceans, swarm by swarm, a recent study says.

Time to put Darwin in his Place

Charles Darwin would be 200 years old this week. And after all these years, people are still arguing about the theory of evolution that he fathered.
[..]
But there's another reason for the ongoing debate that may surprise you: The terms "Darwinian evolution" and "Darwinism" — used frequently by scientists and the media — are misleading.

Friday, February 6, 2009

New post format: Links for 2.6.09

I realized the other day that I have not posted anything here for a long time: Just about a month. I am going to start a new type of post - the links dump. Just a bunch of links to things around the Interwebs that I find interesting/important/amusing. They won't all be science-related - I do enjoy reading about things besides science.

Energy Drinks: The coffee of a new generation?

Several studies have demonstrated that strong doses of caffeine can increase hypertension, cause heart palpitations, provoke irritability and anxiety as well as cause headaches and insomnia. Health Canada does not recommend consuming more than two cans per day.

What causes schizophrenia?

Researchers in Sweden have revealed a surprising change in brain biochemistry that occurs during the training of working memory, a buffer that stores information for the few second required to solve problems or even to understand what we are reading. The discovery may have implications for understanding disorders in which working memory is deficient — such as schizophrenia and attention deficit hyperactivity disorder (ADHD).

Scientists find world's largest snake

The scientists estimate the snake lived 58 to 60 million years ago and was around 13 metres long. The giant, found in northeastern Colombia, dwarfs modern pythons and anacondas which usually don't exceed 6-6.5 metres and are thought to be the largest living snakes.

Amid rising childhood obesity, preschoolers found to be inactive

They found that the preschoolers were inactive for much of their preschool day, with 89 percent of physical activity characterized as sedentary. Even when they played outside, a time when children are expected to move around, 56 percent of their activities were sedentary


A much earlier start for animals


Where did all the animals come from? The fossil record is virtually animal-free up until the Cambrian Explosion 540 million years ago, and then--boom--thousands of critters of all shapes and sizes show up. The mystery has plagued scientists for more than a century and a half, beginning with Charles Darwin. Now, with a brilliant bit of detective work, researchers have located our missing ancestors.

Wednesday, December 17, 2008

Why do we yawn?

New research into the biological basis of yawning will be published soon in the journal Animal Behaviour (news summary can be found here). Researchers at Binghamton University used a species of parakeet as a model organism, since they have relatively large brains, and do not exhibit contagious yawning, as has been seen in humans and other animals.

In their study, they subjected the birds to three different temperature conditions: Warm, normal (control) and slowly increasing. They found that only the third condition had a significant effect on yawning frequency. Their conclusion is that yawning functions as a brain-cooling mechanism, much like a cooling fan on a laptop. When the environment is cooler than the body/brain temperature, taking air in quickly will function to cool the facial blood, which in turn will cool the brain. This leads to an increase in arousal, so those early morning yawns may function similar to a cup of coffee in providing a jolt of energy.

This explains the most common occurrences of yawning. Exhaustion and sleep-deprivation have been shown to increase brain temperature, so yawning in these states would make sense. In addition, yawning may be able to be used as signs of brain cooling problems, which occur in diseases such as multiple sclerosis.

The authors also point out that yawning should no longer be viewed as a sign of boredom, but as an indication of attentiveness. I will try to remember that during my next PowerPoint lecture.

Tuesday, November 25, 2008

Thanksgiving naps - is it the tryptophan?

We most likely all know someone who, after a large Thanksgiving meal, will move to the couch and take a nap, possibly blaming the high level of tryptophan in turkey for making them so tired. So what is tryptophan, is there a high amount in turkey, and does it really make us sleepy?


Tryptophan (see figure at left) is one of the 20 naturally occurring amino acids that make up the proteins in our body. Since humans are unable to synthesize tryptophan from basic building blocks, we must consume it in our diet. There are ten essential amino acids that we must consume in adequate amounts: Arginine (only for young), histidine, isoleucine, leucine, lysine, methionine, phenylalanine, threonine, tryptophan, and valine.

So where does the link between tryptophan and sleep come from? Tryptophan is a precursor in the synthesis of two important signaling molecules, serotonin and melatonin (see pathway at right). Serotonin is a neurotransmitter that has multiple effects in both the central and peripheral nervous system. In the CNS, it has been shown to regulate sleep and mood. The effects of the hormone melatonin are opposite those of serotonin: What one inhibits, the other will activate.

So is there enough tryptophan in turkey to account for the sleepiness we feel after Thanksgiving dinner? According to this chart, turkey falls somewhere in the middle range as far as grams of tryptophan per 100 grams of food, with 0.24 g tryptophan per 100 grams of turkey. Compare this with egg whites, which have 1.00 g tryptophan per 100 g (dry), or Parmesan cheese, which has 0.56 g tryptophan per 100 g. Additionally, tryptophan is converted to melatonin in the intestine, where it functions to regulate digestion (peristalsis). Very little of this intestinal melatonin will enter the blood stream to get to the brain and make us feel sleepy, although there is evidence that if there is an excess in the intestine, some melatonin will leak into the blood stream. There is also a link between extra tryptophan in the diet and melatonin in the bloodstream. This increase in melatonin level has been shown to cause a phase shift the body's circadian rhythm, the normal cycle of resfulness and alertness that is common in all living things. This phase shift may make our bodies think it is later than it actually is, which contributes to a feeling of sleepieness. Interestingly, this phase shift may also contribute to feelings of wakefulness later in the night.

However, these studies were done in rats and chickens with pure tryptophan introduced directly to the stomach. The problem with this is that you do not eat a big plate full of tryptophan on Thanksgiving, or even a big plate of only turkey. You eat a big plate of turkey, stuffing, mashed potatoes, gravy, dinner rolls, pumpkin pie, etc. Adding all these extra nutrients will affect the absorption of melatonin into the bloodstream. Another problem is that tryptophan works best to stimulate sleep on empty stomach - something that is very rare after Thanksgiving dinner.

So what causes the sleepies? There are a few other suspects associated with Thanksgiving dinner. Carbohydrates, such as the starch found in potatoes, stuffing and bread may indirectly lead to an increase in tryptophan in the blood. Fats tend to slow down digestion of all parts of the meal, which makes digestion take longer and lead to longer periods of fullness. If there is alcohol served at dinner, it will function as a general depressant of the central nervous system.

In my opinion, the most likely culprit is simply the size of the meal. The typical Thanksgiving dinner contains more than 4000 calories. The USDA recommends about 2500 calories per day, so some people are basically eating two days worth of food in one sitting. When you are digesting, the body diverts blood flow away from the extremities and brain to the digestive system. This is why it often feels colder outside after eating - less blood in the extremities to keep them warm. Less blood to the brain means less oxygen, which may make you feel tired. There are a few calorie calculators out there for you to try to regulate your food intake. They are not perfect, but they will give you a rough idea of how much you are eating.

So what should you do? I am going to eat a small breakfast, probably not much lunch and try to go light on the appetizers. Then I can eat as much at dinner as I want to, and not worry about it. Thanksgiving is only once a year, might as well celebrate. Its not like the football games are going to be any good.

Saturday, November 15, 2008

History in (and of) Photos

As we enter into our discussion of DNA, I would like to take the time to point out the interesting story behind one of the more well-known photographs in science.



The photo shows up everywhere, it is used as the frontspiece to the chapter in our textbook, and is probably found in every biology textbook published since 1970 or so. As a biologist, I think it ranks with this picture in historical importance; maybe not in total brain power, but at least in terms of the public consciousness. More people have seen the picture of Watson and Crick than of the 1927 physics meeting.

So what is the history of this picture; why, how, and when did it become so famous and widely used?

The picture was taken by Anthony Barrington Brown on May 21, 1953, about a month after publication of Watson and Crick's results on April 25. There were a total of eight photographs taken that day, of which three are commonly reproduced: the famous one above, the slightly less staged version shown below, and one more of Watson and Crick drinking tea (or coffee) in their office. The other prints are not widely reproduced, and a Google Image search failed to uncover them.



Barrington Brown's own account of the day the photographs were taken is interesting. A friend of Barrington Brown's contacted him and asked him to take some pictures for a story that would be sent in to Time magazine. Barrington Brown describes his first meeting with Watson and Crick, and the circumstances behind the posed pictures:

I was affably greeted by a couple of chaps lounging at a desk by the window, drinking coffee. "What's all this about?" I asked. With an airy wave of the hand one of them, Crick I think, said "we've got this model"
[...]
Anyway, I had only come to get a picture so I set up my lights and camera and said "you'd better stand by it and look portentous" which they lamentably failed to do, treating my efforts as a bit of a joke. I took four frames of them with the model and then three or four back with their coffee.


The picture was not used by Time, nor did it appear in a story in the campus newspaper Variety. Barrington Brown was paid 52 pence for the photos, and they were forgotten by all, including the photographer. Up to the awarding of the Nobel Prize in 1962, there appears to be no record of the photos being widely published or distributed.

In 1968, James Watson's autobiographical tale of the discovery of the DNA sttructure, The Double Helix was published. The popularity of the book greatly increased demand for pictures of the pair, and the Barrington Brown photo, which appears in the book, best seemed to capture the personalities of the researchers. Barrington Brown has never received royalty payments for the use of his photos, though he is actively pursuing them now.

In the past 40 years, the photographs have achieved near iconic status, not just of Watson and Crick's discovery, but of scientific research in general. A testament to the iconic stature of the photograph is the fact that Watson and Crick got together nearly 40 years later in an updated version of the photograph.

Thursday, October 30, 2008

Basis for gender identity

Regarding our discussions in class the last few days, I have done some research into gender identity and gender roles. I found a few good articles, including this one by Ghosh and Walker, which is geared toward the medical/scientific community, this one by Brown, which is more for the public, and I found the short story I had mentioned, X: A Fabulous Child's Story, which I highly recommend reading.

First, some definitions (from the first article by Ghosh and Walker), first of gender identity and gender role:

Gender identity is defined as a personal conception of oneself as male or female (or rarely, both or neither). It is intimately related to the idea of gender role, which is defined as the outward manifestations of personality that reflect the gender identity. Simply put, gender identity is a self-label; gender role is a label given by society because of behavior and appearance. For example, if a person thinks of himself as a male and identifies himself as such, then his gender identity is male. However, his gender role is male only if he demonstrates typically male characteristics in behavior, dress, and/or mannerisms.


So gender is more of a social/psychological construct than an absolute biological outcome. Biology does determine the sex of an individual, which is often confused with the term gender:

The 2 terms sex and gender are often used interchangeably in the vernacular. However, [...] these words are not synonymous. [...] Sex, from the Latin word sexus, is defined by the gonads, or potential gonads, either phenotypically or genotypically. It is generally assigned at birth by external genital appearance.

If an intersex condition is present, one sex is often chosen with the intention of making social interactions and rearing simpler. Gender comes from the Latin word genus, meaning kind or race. It is defined by one's own identification as male, female, or intersex; gender may also be based on legal status, social interactions, public persona, personal experiences, and psychologic setting. Stating that sex is biologically determined, whereas gender is culturally determined, is fair.


So obviously, sex is determined by basic biology - XX for females, XY for males. The Y chromosome is the key; it encodes a gene named SRY, or testes determining factor (TDF). During the first 8 weeks of gestation, all fetuses are female. Around the eighth week, TDF is expressed, which leads to the development of testes. The testes begin producing testosterone, which is then converted to dihydotestosterone, the key hormone in virilization (making the fetus male). In the absence of the Y chromosome,the fetus will continue along the female developmental pathway. So that explains sex, what about gender identity?

Unfortunately, much of our understanding of gender identity stems from studying gender identity disorder patients, in which the process of gender identity development is believed to have misfired. This may be a useful strategy, but it is also like trying to figure out how a car runs by visiting a junkyard.

It is thought that the intrauterine hormone exposure sets a gender bias early in fetal development, which explains why female sex most often aligns with female gender identity, and male sex with male gender identity. There are other prenatal factors:

The environment in which a baby is reared with respect to gender begins to take shape prior to birth. Prenatal ultrasonography now allows the sex of a fetus to be determined quite accurately. In families who receive this knowledge of the child's biological sex, parental planning and reactions are often tailored by it. Names, items of clothing and toys, even specific thoughts about the baby, may be different depending on the anticipated sex. Thus, a preformed idea of the child's preferences is in place even before the child is delivered.


So a mother thinking about her child as a "boy" or "girl" and buying blue or pink drapes for the nursery has an effect? Personally, I am not sure about that, it seems like a stretch.

After birth, the parents are instrumental in reinforcing gender roles: little girls are hugged and cuddled with more, little boys wrestle and play with trucks. (According to Ghosh and Walker, this is more evident with fathers than mothers.) Gender identity may come from and be reinforced by these parentally-installed gender roles, and by 3-4 years old identity may be firmly set. Interestingly, gender-variant behavior seems to be better tolerated in females ("tomboys") than in males ("sissy-boys"), at least in Western society.

Looking at some biological bases of gender identity, there are a few chromosomal abnormalities and other mutations that can lead to sex or gender issues. In Turner's syndrome, the individual has only one X chromosome (XO genotype). These individuals are anatomically female, but are often infertile. Although the gender identity is usually reported as female, the infertility may lead to questions about gender role. Klinefelter's syndrome results from an extra X chromosome (XXY). Because of the presence of the Y chromosome, the fetus will generally develop as male. However, during puberty blood testosterone levels are lower than normal (XY) males, which leads to appearance of secondary female sexual characteristics, such as gynecomastia. These can lead to psychological problems and questions about gender identity.

Non-chromosomal causes include congenital adrenal hyperplasia (CAH) and androgen insensitivity syndrome. In CAH, a genetically female (XX) fetus is exposed to high levels of the hormome cortisol while in the uterus. This leads to enlarged external female genitalia, which sometimes are mistaken for male genitalia at birth. If the diagnosis is not made until puberty, as was often the case, these children were often raised as males, which can lead to gender identity problems when the female sex is revealed.

So is there a biological basis for gender? Since gender is a social (for gender roles) or psychological (for gender identity) construct, biology cannot be the only determinant. However, as outlined above for the disorders, there may be biological factors that influence gender. It seems to me that how a child is raised, the parental influence on gender roles, is the most important factor.

Tuesday, October 14, 2008

Nobel and IgNobel

In case you missed it, the 2008 Nobel Prizes were awarded last week. The prize for physiology and medicine was split between three researchers, one who discovered human papilloma virus (HPV) and its link to cancer. The other two researchers were among the fist to discover human immunodeficiency virus (HIV) and its link to AIDS. There is a fair bit of controversy over who should get credit for the discovery of HIV. The Nobel committee decided to reward the French group, while ignoring the American contribution. Of course, I may be a little biased, since Robert Gallo is at the University of Maryland.

The prize for chemistry went to three researchers involved in isolating, cloning and basic research on green fluorescent protein (GFP). GFP was first isolated in jellyfish, and has lead to a revolution in molecular biology. Most likely, there are few molecular research laboratories that do not use some form of GFP in research right now. And you can make cool stuff like this. Or this. Or... yeah you get the idea.

As important as the Nobel Prizes are, there is an interesting take on them here. Very interesting read; if you have time and are contemplating a career in the sciences I highly recommend reading it.

Almost as prestigious as the Nobel Prizes are the IgNobel Prizes, which
honor achievements that first make people laugh, and then make them think. The prizes are intended to celebrate the unusual, honor the imaginative -- and spur people's interest in science, medicine, and technology.


The list of 2008 (and past years) winners can be found here. Which award would you rather receive?